Hands-on Training Course Flow Chemistry

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Hands-on Training Course
Flow Chemistry,
Microreactors & Bioreactors
for R&D and Process Engineers

Wednesday April 9 2014
Radboud University Nijmegen





















Time for a major breakthrough in application of FLOW CHEMISTRY

Chemical process industry is a key factor in the economy of the West European countries ever since the second half of the 20th century. The Rotterdam / Antwerp / Ruhr region still is the greatest industrial complex in chemicals in the whole wide world.

These days the time is right for a big transition in this industry, towards more intensified processes, with higher yield, less foodstock and lower energy consumption. Flow Chemistry is the obvious new paradigm for achieving this.

During the first one and a half decade of the 21st century, a number of academia, technologists and entrepreneurs picked up the opportunities of bringing together both the challenge in chemical research and industry and the chances brought by new micro nano technologies. The technology of today enables, on a commercial basis, a major breakthrough in applying Flow Chemistry.

However, so far only a limited number of people know how Flow Chemistry exactly works and what the opportunities really are, both in research and production.

MinacNed, being a quite young trade association in micro nano technology, is proud to be able to present a hands-on training course for
process technology specialists, lab researchers, process engineers and business developers from chemical industry, pharma and research institutes.

The idea is that during the day all participants experience the features of the experiments mentioned in the program. Participants will go around in the lab and get instructions to practice each experiment in a group of about seven people per session.
Organizing this training course on a not for profit basis, MinacNed acknowledges Radboud University Nijmegen for hosting this first edition of the Hands-on Training Course Flow Chemistry.


1 = Reaction Technology
2 = Flow Chemistry Analysis
3 = Flow Control & Bubble Production
4 = Flow Chemistry Equipment

1.  Reaction technology


Flow chemistry testing your process
on a lab scale

See what your proposed process is doing on the flow, very fast view in a controlled reaction, in only ten minutes time.

Photochemistry in continuous flow offers multiple advantages over its batch-wise analogue. In particular, temperature control during a photochemical reaction is crucial due to possible thermal side products.
A crucial advantage of flow chemistry is the precise temperature control. This is exemplified using a photo switchable dye in a continuous flow in our microreactor platform FlowStart Evo expanded with one of our photochemistry sets and an additional microreactor.




Up scaling flow chemistry for industry

Building a ‘plant’ for 100-200 ton/year of Flow Chemistry product.

The FlowFlex has evolved over Flowid’s extensive project experience into a balanced, easy to operate and versatile platform. A unique approach has been followed: designing by scaling down production setup. It is designed to perfectly fit a laboratory environment. It distinguishes itself because it is equipped with high quality parts, sensors, safety and control features. The FlowFlex is suited for both experimental work and lab productions, a plant in your fume hood.





The innovation and application of flow chemistry

Synthetic reaction and analysis: five samples
in 30 minutes, the promise for industry, even for oil and gas

Radboud University Nijmegen

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2. Flow chemistry analysis


Analysing hydrogen reactions

Working with the hands on H-Cube system,
      as an asset for every chemistry lab




Optimization of flow syntheses through  multiple FlowIR instruments

FlowIR is a dedicated Fourier Transform Infrared Spectroscopy (FTIR) instrument for real-time monitoring of continuous flow chemistry. FlowIR is extremely small making it possible to place anywhere within the continuous reactor setup.

Mettler Toledo


3. Flow control & bubble production


Coriolis mass flow controllers with pump steering

In the experiment you will gain insight into the control stability, the speed and scalability of  the Coriolis mass flow controller based on pump steering The current flow range (from 0.005 until 600 kg/hour) fits in perfectly on the micro reactor technology and offers possibilities to upscale to pilot plant level. Besides measuring mass flow, it is also possible to control the flow by direct feedback to the pump. During the Hands-on Training Course the Coriolis mass flow controller based on pump steering is demonstrated.  Besides that you can discus all your questions regarding the flow control with the specialist of Bronkhorst. 

Bronkhorst Nederland



A parallel droplet generation system

In this demo you will learn more about:

  • High throughput droplet generation of oil-in-water and water-in-oil droplets
  • Increased throughput by parallelization of droplet production nozzles
  • Possibility to play with flow rates and thereby observe the influence on droplet size and frequency

Micronit Microfluidics

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Monitoring and controlling the flow-rates in your microfluidic system

Flow-rate control with pressure actuation in microfluidics applied to co-flow or droplet formation.



4. Flow chemistry equipment


Equipment for automated combinatorial experiments in flow chemistry

Multi Experiment scale reactions showing high yield and seamless scale-up at varying temperatures and concentrations.

FlowSyn Automated Loop Filling (FlowSyn Auto-LF) is a powerful and highly efficient module for running multiple experiments with multiple reagent inputs under different sets of  conditions.
The clever simultaneous loop filling and fraction collection saves valuable time, while the integrated wash steps prevent cross-contamination. Interactive displays of pressure and temperature on PC allow real-time reaction monitoring as well as data logging.

The FlowSyn and Polar Bear Plus scale flow reactions from mg to multiple Kg per day. Completely automated multi step reactions from -90°C to 300°C and up to 200 bar with excellent chemical resistance.




Integrated flow chemistry system

Practising the modular approach for lab and production.




09.30 – 09.50

Welcome with coffee and tea

09.50 – 11.00

Plenary session

09.50 – 10.00

Opening & introduction

10.00 – 10.20

Flow chemistry in motion

Status-quo Flow Chemistry & Equipment
Requirements, Modularity, Scalability
Selected Examples, overview of current practice
Costs & Economics, arguments to invest


Stephanie Peschke & Anne Kaaden, Ehrfeld Mikrotechnik BTS GmbH
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10.20 – 10.40

How to educate the new generation of researchers and engineers
in microfluidics and flow chemistry

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Floris Rutjes, Radboud University Nijmegen
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10.40 – 11.00

Coffee and tea break

11.00 – 12.15

Hands-on training on equipment / experiments

11.15 – 11.45

1.1 1.2 1.3

11.15 – 11.45

2.1 2.2

11.45 – 12.15

1.1 1.2 1.3

11.45 – 12.15

2.1 2.2

12.15 – 13.15


13.15 - 14.15

Hands-on training on equipment / experiments

13.15 – 13.45

3.1 3.2 3.3

13.15 – 13.45

4.1 4.2
13.45  14.15 3.1 3.2 3.3

13.45  14.15

4.1 4.2

14.30 – 15.30

Hands-on training on equipment / experiments

14.30 – 15.30

1.1 1.2 1.3

14.30 – 15.30

2.1 2.2

14.30 – 15.30

3.1 3.2 3.3

14.30 – 15.30

4.1 4.2

15.30 – 15.45

Coffee and tea break

15.45 – 16.15

Flow chemistry and the sense of urgency for process intensification: opportunities for process industry?

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Kees Biesheuvel, DOW Chemical
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16.15 – 17.00


  • What can be done with flow chemistry, microfluidics and process technology?
  • What do we expect the coming years?
  • What are the next steps?



Registration fee:

Non-member fee:

€ 135,- excl. VAT

€ 163,35 incl 21% VAT

Member fee:

 € 95,- excl VAT

€ 114,90  incl 21% VAT

The Hands-on Training Course fee includes drinks and lunch.

*- The member fee is applicable for members of MinacNed, COAST, FHI and NPT.

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Course Venue:

Radboud University Nijmegen
Heyendaalseweg 135; 6525 AJ Nijmegen


Martijn Reinhold
P.O. Box 366
Phone: +31 (0) 33 465 75 07
Email: Dit e-mailadres is beschermd tegen spambots. U heeft Javascript nodig om het te kunnen zien.
Internet: www.minacned.nl


This Hands-on Training Course is organized in collaboration with:

coast COmprehensive Analytical Science and Technology (COAST) 
 branche ia wit 135  FHI – Industrial Automation
nieuw-logo npt 135  Nederlandse Procestechnologen (NPT)