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Nano-metrology lab on a chip’ within reach thanks to new compact, optical sensor.

Researchers at Eindhoven University of Technology have developed a new, integrated optical sensor that provides increased resolution in measurements and paves the way for fully integrated and compact optical sensors including lasers and detectors for on-chip sensing platforms. Such sensors could play a pivotal role in accurate displacement and force measurements at the nanoscale, which is crucial for microchip and nanodevice design and evaluation. This research has been published in Nature Communications.

In the age of nanoelectronics, precision is the order of the day. For example, nanostructures can be monitored with nano-optical instrumentation – tiny, light-based systems that measure the smallest of surface variations, forces and movements. As resolution and speed are essential, optical read-out sensors based on optomechanical systems are frequently used in sensing applications such as in atomic force microscopes (AFMs). These devices generate sub-nanometer resolution images by measuring the laser light reflected by the deflection of a cantilever over a surface of interest.

However, traditional laser-based approaches such as those in AFMs can be bulky, which along with the demand for lower cost and higher resolution, motivates the need for an alternative approach. Thanks to developments in nano-optomechanical systems (NOMS), compact optical sensors for the measurement of motion, force, and mass at the nanoscale are achievable. A limiting factor though is the need for a tuneable laser with a narrow linewidth, which can be difficult to adequately incorporate on a device.

To circumvent this issue, Tianran Liu, Andrea Fiore, and colleagues from the Institute for Photonic Integration at TU/e designed a new optomechanical device with a resolution of 45 femtometers (which is about 1/1000 the size of the smallest atom) in a measurement time of a fraction of a second. Crucially, the device has an ultrawide optical bandwidth of 80 nm, removing the requirement for a tuneable laser.

TU Eindhoven New integrated device for nanometer-scale sensingWaveguides and large wavelength range

The sensor is based on an indium phosphide (InP) membrane-on-silicon (IMOS) platform, which is ideal for including passive components such as lasers or detectors. The sensor itself consists of four waveguides – structures that restrict light signals to a particular path and direction – with two waveguides suspended above two output waveguides. When a suspended waveguide is pushed towards the output waveguides on the InP membrane, the relative amount of signal carried by the output waveguides varies. Fabrication takes place via a series of lithography steps to define the waveguides and cantilever, and the final sensor consists of the transducers, actuator, and photodiodes.

One of the key advantages of this sensor is that it operates in a large range of wavelengths, which eliminates the need for an expensive laser on the device. In terms of cantilever deflection, the sensor also replicates the resolution of cantilevers in traditional, but bulky AFMs. Using this new device as a foundation, the researchers plan on developing an entire “nanometrology lab” integrated on a chip that can be used for semiconductor metrology and help in the design of the next generation of microchips and nanoelectronics.

 

 

Full paper: Tianran Liu et al., “Integrated nano-optomechanical displacement sensor with ultrawide optical bandwidth”, Nature Communications, (2020), doi: 10.1038/s41467-020-16269-7.

Source: TU Eindhoven news item

Surfix B.V., together with its shareholders Qurin Diagnostics B.V. and LioniX International B.V., already successfully developing bio-photonic nanochips for cancer detection and other applications, announced an accelerated development plan to allow mass-scale COVID-19 diagnosis and immunity detection with the financial support and in close collaboration with PhotonDelta.

The desktop testing device will yield reliable test results within 5 minutes and is scheduled to be available for commercial exploitation within 6-9 months. The device will be built around a photonic biochip using LioniX’ mature and proven silicon nitride based integrated optics technology (TriPleX™), a key technology within the PhotonDelta ecosystem. The surface functionalization and biochemical assay development are provided by Surfix and Qurin Diagnostics, respectively. The combination of these disciplines enables a successful, fast and accurate virus detection platform. The development will be supported by and in tight collaboration with Photon Delta (a Dutch public private partnership). The PhotonDelta support will be both in co-funding as in further future upscaling and exploitation.

Qurin Diagnostics, Surfix and LioniX International  are already working together closely on early cancer detection and have realized an ultra-sensitive biochip sensor array which will be applied for early cancer detection using urine as a liquid biopsy.

Qurin Diagnostics

Coenraad K. van Kalken, CEO of Qurin Diagnostics, said ”This collaboration confirms our strategic vision that the ultrasensitive biochip we’re jointly developing for mass scale, low-cost cancer screening is broadly applicable in  biological agri-food markets as well as in other biomedical fields. All these fields need highly accurate molecular diagnosis technology at lower cost than complex and labor intensive molecular technologies, currently used.”

Surfix

Luc Scheres CTO of Surfix said “We have developed specific nanocoatings which enhance the sensitivity, limit of detection and reliability of the photonic biochip. Of course every application comes with its own specific challenges and demands, so close collaboration with experts from other disciplines is essential to successfully develop a diagnostic test. Therefore, we are happy to strengthen our collaboration with LioniX International and Qurin Diagnostics for the accelerated development of a corona virus test.”

Lionix International

“The TriPleX™ platform has shown its capabilities and possibilities for high volume cost effective cancer diagnostics and investing in this new application is not merely a commercial driven choice, but also driven by societal importance. Since we have a solid technology base and reliable collaboration partners, who also enabled the cancer diagnostics measurements, we have large confidence in realizing a successful COVID-19 test.”, said Arne Leinse, CEO of LioniX International.

PhotonDelta

“‘This is a great example of a joint effort of partners in the PhotonDelta ecosystem to develop meaningful, low costs and effective solutions enabled with integrated photonics technology. The initiative builds upon our knowledge on ultra-sensitive biochips, which might be of utmost relevance in detecting the current COVID-19 crisis. Bio sensing is one of the long-term development programs (roadmap) within PhotonDelta where industry, universities and the entire PhotonDelta ecosystem work together on next generation solutions and testing devices on viruses and other diseases‘’, said Ewit Roos, CEO of PhotonDelta

Download the full press release (PDF)

Read more about MinacNed partners Lionix International BV and Surfix

Read more about PhotonDelta and Qurin Diagnostics